Ongoing Projects > Renal Mass Study

Global Renal Mass Study - A prospective International Study on Indications, Treatment Modalities and Outcomes 

During the past years we are witnessing an increased interest in Renal masses. Two main reasons are responsible for this: the increasing diagnostic incidence which leads to incidental discovery of small renal masses and the development and consolidation of partial nephrectomy and minimal invasive surgical treatments, the latter including the laparoscopic approach and ablation techniques.

However, there are some fundamental differences concerning indication for surgery, experience and technique used mainly based on institutional characteristics. Those factors may modulate outcomes. Moreover, specific patient and technique factors may influence treatment related morbidity. In this prospective study we aim to assess on a global basis the indications, treatment modality and outcomes of instrumental treatment for renal masses including (laparoscopic/robotic) radical or partial nephrectomy and (percutaneous/laparoscopic assisted) ablative treatments. Each centre participating in this project will include during a one-year period all the patients treated at their site, with the diagnostic of renal mass.

Download the Renal Mass protocol

Primary study objective:

To assess the current patterns of surgical or instrumental treatment and indications for RCC treatment and treatment outcomes in terms of objective and subjective improvement.


Secondary study objectives: 

  1. To assess the peri-operative morbidity (30 days) by using the Clavien score.
  2. To define risk factors for the development of peri-operative morbidity after instrumental treatment.
  3. To assess quality of life related to the different treatment modalities.
  4. To asses pathological characteristics of the renal masses

Eventually collection on long-term follow (5-10 years) up would be recommended to all participant centres. Long-term data can be used to correlate initial pathology and treatment modality with oncological outcome as well as to test the predictive ability of different staging systems (TNM / Risk systems)



  • Inclusion of data on all consecutive patients treated during a one-year period.

  • Study initiated from each site once the first patient is enrolled. Each centre will close its participation exactly one year after inclusion of the first patient.

  • There is no minimum or maximum of number of sites participating in this study, however, all sites must receive prior approval of the CROES council.

  • Subject to the approval of the CROES council, the lead investigator at study sites must be a member of the Endourological Society and in good standing. Subject to the approval of the CROES council, study sites may be proposed by the members from the Steering committee or on recommendation from a third party.

  • Electronic database will be maintained at the central data collection site selected by the CROES council and shall be updated on a regular basis as determined by the CROES council. A manager, selected by the CROES council, at the central data collection site will maintain and coordinate the data collection.  

  • Prior to approval of the site by the CROES council, for quality assurance, either an IRB approval or a letter from the principal investigator of the study site assuring the quality and ethical standards of data collection will be provided.

  • The members of the study group will receive feedback on the data collected on a regular basis, as determined by the CROES council. 

  • The data analysis shall be the responsibility of the Steering committee for the study group.

  • The Steering committee shall be comprised of 6-8 international members and a chairman. A good balance among the different treatment specialists is desirable. Representatives of the CROES council may be joining during the Steering committee meetings. Representatives from the supporter of the study will join the Steering Committee.


Pilar Laguna (the Netherlands)
Adrian Joyce (UK)
Ferran Algaba (Spain)
Hein Van Poppel (Belgium)
Jaime Landman (USA)
Inderbir Gill (USA)
Jeffrey Cadeddu (USA)
Ralph Clayman (USA)
Benjamin Lee (USA)
Guillermo Gueglio
Markus Hohenfellner

Sybill Storz
Sybill Storz
Sybill Storz
Mr. Helmut Wehrstein
Mr. Eric Dourver

Since the company KARL STORZ was founded in 1945, more than half a century has passed – a period of time during which the enterprise has written a significant chapter of medical and technological history. Karl Storz had a vision which was transformed into reality and has been extended through to his very day thanks to pioneering discoveries and inventions.

Modern high-technology medical systems consist of components from the most diverse fields of engineering : optics, mechanics and electronics must work in perfect harmony if the instruments are to function as desired. As simple as the requirement for a harmonious interplay of the individual components may sound, its realization is in fact a highly complex matter.

No matter how much meticulous care is given to development, the quality of the end product is decided by day-to-day manufacturing routine. The perfect instrument can only be created when all components are ideally matched and coordinated.

Our company attains this high quality by ensuring that each and every component is developed, manufactured and subjected to a constant quality control process at our own company. This concept guarantees a maximum of functionality and quality for each individual endoscopic system. The continuity of this quality-consciousness is ensured by the company´s tenet of training its employees from all sectors at our own company.

KARL STORZ will maintain and extend even further its leading position in technological development. However, genuine progress is rarely spectacular – it is the result of countless individual steps that are subjected to repeated scrutiny. 

In accordance with this philosophy, KARL STORZ decided to support the CROES study. This kind of study, exploring the different ways of treatment and using different technologies, is an ideal field to collect a wide variety of information and to prepare the future.    

Argentina Hospital Italiano Gueglio
Australia Melbourne University Bolton
Australia VMO at Westmead and Blacktown Hospital, Sydney Bariol
Austria Medizinische Universität Graz Zigeuner
Belgium AZ Groeninge Billiet
Belgium Maria Middelares Ameye
Belgium University Hospital Leuven van Poppel
Bosnia University of Sarajevo  Bajramovic
Chile Hospital Militar de Santiago Coz
China Changhai Hospital Sun
Czech Republic Masaryk University Pacik
Czech Republic University Hospital Plzen Hora
France AMC Bordeaux Bernhard
France CHU Amiens Saint
France CHU Henri Mondor Abbou
France Hospital Claude Huriez Zini
France Hospital Conception, Marseille Lechevallier
France Rennes University Hospital Verhoest
France Université Paris Descartes barret
Georgia Tbilisi State University Karazanashvili
Germany Helios Kliniken Frede
Germany Klinikum Sindelfingen Knoll
Germany SLK-Klinikum am Gesundbrunnen, Heilbronn Rassweiler
Germany Uni Heidelberg Pahernik
Germany University Medical Center, Marburg Olbert
Germany University of Tuebingen Schwentner
Greece Aristotle University of Thessaloniki Toutziaris
Greece General Hospital Of Veria Sountoulidis
Greece Sismanoglio Hospital, Athens Skolarikos
Greece University Hospital of Larissa Gravas
Greece University of Patras, Rio-Patras Liatsikos
India Cipto Mangunkusumo Hospital Mochtar
India Hacettepe University Donmez
India Institute of Kidney Diseases and Research Center Modi
India Postgraduate Institute of Medical Education & Research, Chandigarh Singh
India Vedanayagam Hospital & Postgraduate Institute Gopalakrishnan
Iran Hasheminejad Hospital Radfar
Iran Shahid Beheshti University Shakhssalim
Iran Shiraz University Aminsharifi
Italy Azienda Ospedaliero Universitaria di Parma Unità Operativa di Urologia Frattini
Italy Careggi Hospital, University of Florence Crisci
Italy L. Sacco Gaboardi
Italy Maggiore della Carità Hospital, Novara                                                               Volpe
Italy Molinette Hospital Gontero
Italy Ospedale San Giovanni Delia
Italy San Bassiano Hospital Breda
Italy San Luigi Gonzaga Hospital Porpiglia
Italy Second University Hospital, Naples De Sio
Italy Univerity of Foggia Luigi
Japan Kansai University Matsuda
Japan Kyushu University Naito
New Zealand Bay of Plenty Clinical School, Tauranga Gilling
Poland Clinic of Urology Zdrojowy
Portugal Centro Hospitalar de Coimbra Temido
Portugal Centro Hospitalar de Lisboa Leitao
Portugal Hospital Curry Cabral, Lisbon Campos-Pinheiro
Romania Oncological Institute, Cluj-Napoca Petrut
Romania Prof.Dr.Th.Burghele Hospital,Bucharest Jinga Viorel
Romania Timisoara Clinical Emergency Hospital Bucuras
Spain Fundacio Puigvert I.U.N.A. Palou
Spain Hospital Clínico "Lozano Blesa", Zaragoza Sanchez Zalabardo
Spain Hospital General Royo Villanova. Zaragoza Pelegri
Spain Hospital Infanta Sofia, Madrid Alvarez-Maestro
Spain Hospital Miguel Servet de Zaragoza Rioja
Spain Hospital Universitario Rio Hortega, Valladolid Amon
Sweden SUS Forsberg
Switzerland Urologische Klinik Universitätsspital Basel Subotic
Thailand Ramathibodi Hospital, Mahidol university Kijvikai
The Netherlands Academic Hospital of Maastricht Tuytten
The Netherlands AMC Laguna
The Netherlands Isala Klinieken, Zwolle Kums
The Netherlands Maxima Centrum Fossion
The Netherlands The Netherlands Cancer Institute, Amsterdam Bex
The Netherlands University of Leiden Pelger
The Netherlands VU medisch centrum vanMoorselaar
Tunisia Charles Nicolle Hospital Bouzouita
Turkey Akdeniz Hospital Erdogru
Turkey Ankara Atatürk Training and Research Hospital Balbay
Turkey Cerahpasa Turkey Obek
Turkey Ege Turkey Turna
Turkey ESOGU Medical Faculty Urology Baseskioglu
Turkey Gulhane Military Medical Academy                                                                     Ozgok
Turkey Istanbul Bilim University School Of Medicine, Istanbul Kural
Turkey Istanbul Goztepe Training Hospital Yildirim
Turkey Istanbul University Tefekli
Turkey Kecioren Hospital Unsal
Turkey Marmara University Turkeri
Turkey Numune Research and Training Hospital, Ankara Aslan
Turkey Pamukkale University Tuncay
Turkey School of Medicine, Fatih University, Ankara Unal
Turkey Selcuk University Meram Medical School Guven
UK Frimley Park Hospital Barber
UK Guy's Hospital Prokar
UK Leichester University Kockelbergh
UK Pinderfields General Hospital, Wakefield Assimos
UK Portsmouth Hospital Hodgson
UK St.James University Joyce
USA Arthur Smith Institute of Urology, North Shore-Long Richstone
USA Central Ohio Urology Group martin
USA Denver Medical Center Kim
USA Duke U.S.A Polascik
USA Hackensack MC Munver
USA Michigan University Wolf
USA The University of Oklahoma Health Sciences Center, Oklahoma City Wong
USA The University of Texas Southwestern Medical Center Cadeddu
USA Tulane University School of Medicine Lee
USA University of California, Irvine Louie
USA University of Chicago Eggner
USA University of Pittsburgh Medical Center Jackman
USA University of Southern California Aron
Venezuela Carabobo University Escovar
Office   Contact us   Disclaimer   Conditions