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Ongoing Projects > PCNL Study

GLOBAL PCNL OBSERVATIONAL STUDY

During the past years we are witnessing a renaissance of PCNL as primary treatment for renal stones. PCNL is truly on the rise again most probably due to technical refinements of the endoscopic equipment and because of more realism about the efficacy of the SWL therapy.
There are some fundamental (institutional) differences, however, concerning indication for surgery and maybe outcomes. Moreover specific factors may influence treatment related morbidity. In this prospective study we will study on a global base the indications and outcomes of PCNL. Each centre participating in this project will include during a one-year period the patients treated at their site.

 

 

               

Primary study objective:

  • To assess the current indications for PCNL and the treatment outcomes in terms of the stone free rate

Secondary study objectives:

  • To assess the peri-operative morbidity (30 days) by using the Clavien system
  • To define risk factors for the development of peri-operative morbidity after PCNL

 

The following variables will be included to correlate in a logistic regression and uni/multivariate analysis:

  • The use of antibiotics and incidence of infections.
  • The type of access used (balloon versus metal dilators) and the possible differences in morbidity.
  • Specific medical conditions (age, BMI, DM, anticoagulants, cardiovascular disease) versus outcome and morbidity
  • The success of PCNL treatment following prior instrumental treatment for renal stones.
  • Outcomes in complicated cases (mono-kidney, renal congenital anomalies, neurogenic problems)
  • To study preferences in intra-operative technique (device for fragmentation, use of ureteral stents and/or percutaneous drain, kind of guidance for access, puncture site)
  • To study differences between lower and higher volume sites

 

  • Inclusion for a one year period of patients
  • Study initiated per site once the first patient is included
  • There is no upper or lower limit of number of sites participating in this study
  • Study sites should be of good standing and preferably members of the Society of Endourology. The sponsor may propose centres, the members from the Steering committee or on recommendation from a third party
  • Electronic database will be made available. On a regular base an update of the database is provided to the central data collection centre. At the centre a contact person will coordinate the data handling
  • The members of the study group will receive on a regular base an update of the data collected
  • The data analysis is supported by a Steering committee that are members of the study group
  • The Steering committee is composed of 8-10 international members, a chairman and a representative from the sponsor.
Jean de la Rosette (the Netherlands)
Jean de la Rosette (the Netherlands)
Jean de la Rosette (the Netherlands)
Ahmed Tefekli (Turkey)
Jorge Gutierrez (Mexico)
Mahesh Desai (India)
Dean Assimos (Americas)
Roberto Scarpa (Italy)

ARGENTINA, Centro de Litiasis Hospital Italiano, Buenos Aires
ARGENTINA, Urosalud, Buenos Aires
AUSTRALIA, University of Melbourne, Austin Hospital, Heidelberg Vic
AUSTRIA, Medical University of Vienna, Vienna
BELGIUM, UZ Gasthuisberg, Leuven
CANADA,Western University, London
CANADA, Royal Victoria Hospital, McGill University Health Centre, Montreal
CHILE, Hospital San Borja Arriaran, Santiago
CHINA, Yantai Yu Huang Ding Hospital, Yantai
CHINA, Changhai Hospital, Shanghai
CHINA, Renji Hospital, Shanghai Jiaotong University Medical School, Shanghai
CHINA, Peking University First Hospital, Beijing
CZECH REP, University Hospital Brno, Brno
DENMARK, Fredericia Hospital, Fredericia
DENMARK, Herlev Hospital, Herlev
FRANCE, University of Strasbourg, Strasbourg
FRANCE, Service d’Urologie CHU Henri Mondor, Créteil-cedex
GERMANY, University Hospital Mannheim, Mannheim
GERMANY, Asklepios Hospital Barmbek, Hamburg
GERMANY, Universitätsklinikum Gießen und Marburg GmbH, Marburg
GERMANY, SLK-Klinikum am Gesundbrunnen, Heilbron
GERMANY, University of Leipzig, Leipzig
GREECE, University of Patras, Patras
GREECE, University Hospital of Larissa, Larissa
GREECE, Sismanoglio Hospital, Athens
INDIA, Muljibhai Patel Urological Hospital, Nadiad
INDIA, Vedanayagam Hospital, RS Puram
INDIA, Vedanayagam Hospital and postgraduate Institute, Tamilnadu
INDIA, All India Institute of Medical Sciences, New Delhi
INDIA, Postgraduate Institute of Medical education & Research, Chandigarh
INDIA, Institute of Kidney Diseases and Research Centre, Gujarat
INDIA, Lions Kidney Hospital and Urology Research Institute New Friends Colony, New Delhi
INDIA, R. G. Stone Urology & Laparoscopy Hospital, Mumbai
INDIA, Sanjay Gandhi Post Graduate Institute, Lucknow
ISRAEL, Hadassah Hebrew University Hospital (Ein-Karem ), Jerusalem
ISRAEL, Tel-Aviv Sourasky Medical Center, Tel-Aviv
ITALY, University of Modena & Reggio Emilia, Modena
ITALY, Koelliker Hospital, Torino
ITALY, San Bassiano Hospital, Grappa (IV)
ITALY, University of Foggia, Foggia
ITALY, Azienda Ospedaliero-Universitaria Careggi, Firenze
ITALY, Catholic University School of Medicine, Rome
ITALY, Urological Clinic, University of Cagliari, Cagliari
ITALY, Second University of Naples, Naples
ITALY, Azienda Ospedaliero-Universitaria di Parma, Parma
ITALY, Policlinic Hospital S.Orsola Malpighi, University of Bologna, Bologna
ITALY, Istituto Clinico Humanitas, IRCCS, Rozzano (Milan)
ITALY, Università di Torino, Torino
ITALY, Moriggia Pelascini Hospital, Gravedono
JAPAN, Harasanshin Hospital, Fukuoka
JAPAN, Kyorin University School of Medicine, Tokyo
MEXICO, Instituto de Endourologia, Centro Medico Puerta de Hierro and Nuevo Hospital Civil, Universidad de Guadalajara, Guadalajara
THE NETHERLANDS, Erasmus MC, Rotterdam
THE NETHERLANDS, AMC university hospital, Amsterdam
THE NETHERLANDS, Catharina Ziekenhuis, Eindhoven
THE NETHERLANDS, Isala Klinieken, Zwolle
THE NETHERLANDS, Atrium Medisch Centrum, Heerlen
THE NETHERLANDS, St. Antonius Ziekenhuis, Nieuwegein
PORTUGAL, Hospital St. Maria, Lisbon
ROMANIA, Timisoara Clinical Emergency Hospital, Victor Babes University of Medicine and Pharmacy, Timisoara
ROMANIA, Saint John Emergency Clinical Hospital, Bucharest
ROMANIA, University of Targu-Mures Medical School, Targu Mures
ROMANIA, Victor Babes University of Medicine and Pharmacy, Timisoara
SPAIN, Hospital Universitario Rio Hortega, Valladolid
SPAIN, Hospital General Universitario Gregorio Marañón, Madrid
SPAIN, Hospital Galdakao-Usansolo, Bizkaia
SPAIN, Hospital Miguel Servet, San Sebastian – Guipuzcoa
SPAIN, Hospital Miguel Servet, Zaragoza
SPAIN, University Hospital Guadalajara, Guadalajara
SPAIN, Clinical Universitary Hospital Lozano Blesa, Zaragoza
SWEDEN, Malmö University Hospital, University of Lund, Lund
SWEDEN, University Hospital Orebro, Orebro
THAILAND, Ramathibodi Hospital, Mahidol University, Bangkok
TURKEY, Istanbul Bilim University and Group Fiorence Nightingale Hospital, Istanbul
TURKEY, Istanbul University, Cerrahpasa School of Medicine, Istanbul
TURKEY, Haseki Teaching and Research Hospital, Istanbul
TURKEY, Ege University School of Medicine, Izmir
TURKEY,Akdeniz University Hospital, Antalya
UNITED KINGDOM, Barts; The London NHS Trust, London
UNITED KINGDOM, The Scottish Lithotriptor Centre, Western General hospital, Edinburgh Scotland
UNITED KINGDOM,North Bristol NHS Trust, Bristol
UNITED STATES,University of Pittsburgh Medical Center, Pittsburgh
UNITED STATES, University of California, Los Angeles
UNITED STATES, Methodist Hospital Institute for Kidney Stone Disease, Indianapolis
UNITED STATES, University of California, Irvine
UNITED STATES, Northwestern University Feinberg School of Medicine, Chicago
UNITED STATES, The University of Texas Southwestern Medical Center, Dallas
UNITED STATES, Duke University Medical Center, Durham
UNITED STATES, Long Island Jewish Medical Center, Arthur Smith
UNITED STATES, University of Michigan Medical Center, Ann Arbor
UNITED STATES, University of Oklahoma Health Sciences Center, Oklahoma City
UNITED STATES, Lenox Hill Hospital, New York
UNITED STATES, UW School of Medicine and Public Health, Wisconsin
UNITED STATES, University of Kentucky, Lexington
Mr. Haruhito Morishima
Mr. Rick Harbuck

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MANUSCRIPTS PUBLISHED/IN PREPARATION

 

1.The Clinical Research Office of the Endourological Society (CROES) percutaneous nephrolithotomy (PCNL) global study: indications, complications and outcomes in 5803 patients

De la Rosette, Assimos, Desai, Gutierrez, Lingeman, Scarpa,  Tefekli

PUBLISHED JOURNAL OF ENDOUROL 2011;25(1):11-17, Times Cited:132

 

2.The Clinical Research Office of the Endourological Society (CROES) Percutaneous Nephrolithotomy (PCNL) Global Study: Tract Dilation Comparisons in 5537 Patients

Lopes, Kandasami, Alken, Silva, Saussine, Shi, de la Rosette

PUBLISHED JOURNAL OF ENDOUROL 2011,25(5):755-762, Times Cited:17 

 

3.Operating times and bleeding complications in percutaneous nephrolithotomy (PCNL): A comparison of tract dilation methods in 5537 patients in the Clinical Research Office of the Endourological Society (CROES) PCNL Global Study

Yamaguchi, Skolarikos, Buchholz, Bueno Chomón, Grasso, Saba, Nakada, de la Rosette

PUBLISHED JOURNAL OF ENDOUROL 2011, 25(6): 933-939, Times Cited:34

 

4.The Percutaneous Nephrolithotomy (PCNL) Global Study: Classification of Complications

Labate, Modi, Timoney, Cormio, Zhang, Louie, Grabe, de la Rosette

PUBLISHED JOURNAL OF ENDOUROL 2011,25(8):1275-1280, Times Cited:36

 

5.The Clinical Research Office of the Endourological Society Percutaneous Nephrolithotomy Global Study: Staghorn Versus Non-Staghorn Stones

Desai, De Lisa, Turna, Rioja, Walfridsson, D’Addessi, Wong, de la Rosette

PUBLISHED JOURNAL OF ENDOUROL 2011,25(8):1263-1268, Times Cited:32

 

6.Supine vs. Prone Position During Percutaneous Nephrolithotomy (PCNL): A Report from the Clinical Research Office of the Endourological Society (CROES) PCNL Global Study

Valdivia, Scarpa, Duvdevani, Gross, Nadler, Nutahara, de la Rosette

PUBLISHED JOURNAL OF ENDOUROL 2011,25(10):1619-1625, Times Cited:24

 

7.Percutaneous Nephrolithotomy Among Patients with Renal Anomalies: Patient Characteristics and Outcomes; a Subgroup Analysis of the CROES Global PCNL Study

Osther, Razvi, Liatsikos, Averch, Crisci, Lopez Garcia, Mandal, de la Rosette 

PUBLISHED JOURNAL OF ENDOUROL 2011,25(10):1627-1632, Times Cited:13

 

8.The Clinical Research Office of the Endourological Society (CROES) Percutaneous Nephrolithotomy (PCNL) Global Study: Nephrolithotomy in 189 Patients with Solitary Kidneys

Bucuras, Gopalakrisnan, Wolf, Sun, Bianchi, Erdogru, de la Rosette

PUBLISHED JOURNAL OF ENDOUROL 2012, 26(4): 336-41, Times Cited:12

 

9. Urinary Tract Infections and Post-Operative Fever in Percutaneous Nephrolithotomy

Gutierrez, Smith, Geavlete, Shah, Kural, De Sio, Amón Sesmero, Hoznek, de la Rosette 

PUBLISHED WORLD JOURNAL OF UROLOGY 2013;31(5):1135-40



10. Management of Single Large Nonstaghorn Renal Stones in the Clinical Research Office of the Endourological Society (CROES) Percutaneous Nephrolithotomy (PCNL) Global Study

Xue, Pacik, Boellaard, Breda, Botoca, Rassweiler, Van Cleynenbreugel, de la Rosette

PUBLISHED JOURNAL OF UROLOGY 2012,187(4):1293-7, Times Cited:8  



11. Lithotrites and post-operative fever: results from the Clinical Research Office of the Endourological Society (CROES) Percutaneous Nephrolithotomy (PNL) Global Study

Chu, Lipkin, Wang, Ferrandino, Preminger, Kijvikai, Gupta, Melekos, de la Rosette

PUBLISHED UROLOGIA INTERNATIONALIS 2013;91(3):340-4



12. Exit Strategies Following Percutaneous Nephrolithotomy (PCNL): A Comparison of Surgical Outcomes in The Clinical Research Office of The Endourological Society (CROES) PCNL Global Study

Cormio, Ibarlucea, Tolley, Sofer, Muslumanoglu, Klingler, Stolzenburg, de la Rosette

PUBLISHED WORLD JOURNAL OF UROLOGY 2013;31(5):1239-1244



13. Percutaneous Nephrolithotomy in Children in Different Age Groups: Data from the Clinical Research Office of the Endourological Society Percutaneous Nephrolithotomy Global Study

Guven, Frattini, Onal, Desai, Montanari, Kums, Garofalo, de la Rosette

PUBLISHED BJUI 2013;111(1):148-156, Times Cited:3



14. The Clinical Research Office of the Endourological Society Percutaneous Nephrolithotomy Global Study: The Influence of Body Mass Index on Outcomes

Fuller, Razvi, Denstedt, Nott, Pearle, Cauda, Bolton, Celia, de la Rosette

PUBLISHED JOURNAL OF UROLOGY 2012,188(1):138-44, Times Cited:20

 

15. The Clinical Research Office of the Endourological Society Percutaneous Nephrolithotomy Global Study: Outcomes in the Super Obese – a Case Control Analysis

Fuller, Razvi, Denstedt, Nott, Hendrikx, Luke, Pal, de la Rosette

PUBLISHED CUAJ 2014;8(5/6):e393-7

 

16. Prospective comparison of outcomes of percutaneous nephrolithotomy in elderly patients versus younger patients

Okeke, Smith, Labate, D’Addessi, Venkatesh, Assimos, Strijbos, de la Rosette

PUBLISHED JOURNAL OF ENDOUROLOGY 2012 Aug;26(8):996-1001.Times Cited:6

 

17. Post-Operative Infection Rates in Low Risk PCNL Patients With And Without Antibiotic Prophylaxis: A Matched Case Control Study

Gravas, Montanari, Geavlete, Onal, Skolarikos, Pearle, Sun, de la Rosette

PUBLISHED JOURNAL OF UROLOGY 2012; 188(3): 843-7.Times Cited:7

 

18. Does imaging modality used for percutaneous renal access make a difference? An analysis of the Clinical Research Office of the Endourological Society (CROES) PCNL Global Study database

Andonian, Scoffone, Louie, Gross, Grabe, Daels, Shah, de la Rosette

PUBLISHED JOURNAL OF ENDOUROLOGY 2013;27(1):24-28, Times Cited:3

 

19. Categorisation of Complications and Validation of the Clavien Score For Percutaneous Nephrolithotomy (PCNL)

De la Rosette, Opondo, Daels, Giusti, Serrano Pascual, Kandasami, Wolf, Grabe, Gravas

PUBLISHED EUR UROL 2012;62(2): 246-255.

 

20. Percutaneous Nephrolithotomy and Chronic Kidney Disease: Results From the Clinical Research Office of the Endourological Society (CROES) PCNL Global Study

Sairam, Scoffone, Alken, Turna, Sodha, Rioja, Wolf, de la Rosette

PUBLISHED JOURNAL OF UROLOGY 2012 Oct;188(4):1195-200.Times Cited:9

 

21. Impact of case volumes on the outcomes of percuteneous nephrolithotomy 

Opondo, Tefekli, Esen, Labate, Kandasami, De Lisa, Shah, de la Rosette

PUBLISHED EUR UROL 2012;62(6):1181-1187, Times Cited:12

 

22. Isolated Upper Pole Access in Percutaneous Nephrolithotomy: A Large Scaled Analysis from the CROES Percutaneous Nephrolithotomy Global Study

Tefekli, Esen, Olbert, Tolley, Nadler, Duvdevani, Sun, de la Rosette

PUBLISHED J OF UROL 2013; 189(2):569-573, Times Cited:2

 

23. Nephrostomy in percutaneous nephrolithotomy (PCNL): does size matter? Results from the Global PCNL study from the Clinical Research Office Endourology Society

Cormio, Preminger, Saussine, Buchholz, Zhang, Walfridsson, Gross, de la Rosette

PUBLISHED WJU 2013; 31(6):1563-1568, Times Cited:3

 

24. Impact of Stone Density on Outcomes in Percutaneous Nephrolithotomy (PCNL): an Analysis of the Clinical Research Office of the Endourological Society (CROES) PCNL Global Study Database

Anastasiadis, Onal, Modi, Turna, Duvdevani, Timoney, Wolf, de la Rosette

PUBLISHED Scand J Urol 2013; 47(6): 509-514

 

25. A Nephrolithometric nomogram to predict treatment success of percutaneous nephrolithotomy

Smith, Averch, Shahrour, Opondo, Daels, Labate, Turna, de la Rosette

PUBLISHED JOURNAL OF UROLOGY 2013;190(1):149-156, Times Cited:8

 

26. Effect of supine versus prone position on outcomes of percutaneous nephrolithotomy in staghorn calculi: Results from the Clinical Research Office of the Endourology Society (CROES) study

Astroza, Neisius, Lipkin, Preminger, De Sio, Sodha, Saussine, de la Rosette

PUBLISHED UROLOGY 2013;82(6):1240-1244



27. Standardization of Patient Outcomes Reporting in Percutaneous Nephrolithotomy 

Opondo, Gravas, Joyce, Pearle, Matsuda, Sun, Assimos, Denstedt. de la Rosette

PUBLISHED JOURNAL Of ENDOUROL 2014; 28(7):767-774  

  



*The proposed authors are nominated by the steering committee of the PCNL study according to the CROES guidelines for publication. The list is not definitive and can be adjusted by the steering committee. 

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