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Ongoing Projects

CROES has created a platform that facilitates research through the global network of CROES. During the past 8 years close to 400 centers have participated in different projects. The initial study on PCNL was most successful and finalized with 28 publications. At present the CROES office is extensively mining the databases of the Global URS, the global Renal Mass study and the NBI randomized study on bladder cancer. Thus far an increasing number of manuscripts are published and more are in preparation. Outcomes from these analyses provided new insights and contribute to the foundation of our knowledge in endourology. 

We have launched several new CROES projects: A RCT, a registry on IRE for PCa, a RCT on SPIES in NMIBC and a Registry of UTUC.  

The first patients have been included in the RCT on IRE for Focal therapy in patients with localized PCa. Also the firstpatients have been included in the registry. CROES welcomes colleges to join the IRE registry and thus collect real life data on IRE treatments. With their help we will be able to obtain insight in indications and outcomes and learn from that. Moreover those colleges will be able to receive feedback from their outcomes compared to performances from other colleagues.

A second RCT has been initiated last year, a multicentre randomized controlled trial in which the recurrence rates of bladder carcinoma between SPIES assisted and WLI assisted TURB are compared. Short and long term follow up will be recorded in order to evaluate the health gains for patients over a longer period. Perioperative (30 days) complications will be compared between the two treatment arms to evaluate the safety of SPIES. We currently have 15 centres that are joining this study and the first patient was included in April 2015. Each centre willing to participate should have enough experience and be familiar with SPIES. A centre is considered to have enough experience when a minimum of 10-20 procedures have already been done with SPIES prior to including patients in this study.

For the Registry of the UTUC we invite all colleagues to join us. Any patient requiring treatment for an upper tract tumor can be included. Treatment can be an open nephroureterectomy or by laparoscopic or robotic approach. But treatment can also include conservative treatment by retrograde Intrarenal surgery. According to CROES methodology, all participating centres worldwide are expected to include all patients they treat for UT-TCC over a five year period and to provide follow up data up to five years; the case-load is not a participation criteria as it is felt to be a potential source for further clinical information.  We aim to enter cases for the oncoming 5 years and have at least 5 years follow up. We currently have about 200 centers that have expressed their interest and we welcome everybody to join us in this endeavour. 


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